By G. F. Rossi (auth.), Professor Jan Gybels, Professor Edward R. Hitchcock, Priv.-Doz. Christoph Ostertag, Professor Gian Franco Rossi, Professor Jean Siegfried, Professor Gabor Szikla (eds.)
Local interstitial radiation remedy of intrinsic and inaccessible mind tumors is faced with significant difficulties: 1. The tolerance of ordinary mind tissue, that's frequently thinking about neighborhood tumor irradiation, i.e. perifocal white subject edema and demyelinating results, is important. 2. info on radiation results of implanted radioactive resources on neoplastic tissue, i.e. facts at the radiosensitivity and at the biology of tumors, are nonetheless broadly unavailable. In medical perform the dose with which to accomplish a given quantity of tumor necrosis is approximately envisioned. This document offers with the experimental findings of Iodine-125 and Iridium-I92 everlasting implants in fit and neoplastic mind tissue. Our personal experimental findings are correlated with experimental information on Yttnul11-l)O irradiation from the literature. The research is directed to assemble facts at the tolerance non-tumoral mind tissue and to aim to set up a dose-response dating. Morphologic alterations within the puppy mind Following Interstitial Iodine-125 Irradiation Iodine-I25 seeds (manufactured by way of three M corporation, St. Paul, M. N.) with an task of 3.55 mCi have been completely implanted lower than stereotactic stipulations into the subcortical white topic of the gyrus coronalis of the left hemisphere in 6 beagle canines. One animal with a non-radioactive seed implanted less than related operative stipulations served as a keep an eye on. The animals have been allowed to outlive 25, forty six, seventy one, ninety four, 248, 368 days, respectively, after the implantation. The keep watch over animal survived forty six days. a close description of the experimental method is given somewhere else sixteen. 17.
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Extra resources for Advances in Stereotactic and Functional Neurosurgery 6: Proceedings of the 6th Meeting of the European Society for Stereotactic and Functional Neurosurgery, Rome 1983
Marked atrophy in the right temporal convolution and tough and rubbery cerebral tissue were found during the right temporal craniotomy. Neuropathological examination revealed moderate to marked gliosis in the temporal cerebral tissue and amygdala. FOG findings, illustrated in Fig. 05) in the right central region. Oxygen-I 5 studies for rCBF, rOEF, rCMRO z revealed a 49% reduction ofrCBF, 12% reduction of rOEF, and 54% reduction of rCMRO in the right anterior temporal region. In the right centroparietal region there was a 26% reduction of rCBF, 11 % reduction of rOEF, and 46% reduction of rCMRO.
Brazier 3 - S applied linear system analysis methods to depth recordings of seizure activity. By estimating coherence and phase between pairs of derivations, she calculated the spread of epileptic discharges within the human brain. BrazierS remarked that "the detection of a source, that drives the abnormal activity to other parts of the brain ... may have a future in terms of therapeutic procedure. The possibility presents itself that a single coagulation either of the locus itself or of the efferent connections from it might replace the more radical therapy of surgical removal of the temporal lobe" .
C. Evans 2, B. Cooke 2, M. Izawa 1, A. Kato 1, P. Gloor 1, W. H. FeindeF, M. Diksicl, and C. J. Thompson 1 With 2 Figures Summary We report here results of positron emission tomographic studies on 14 patients with partial epilepsy using fluorine-18 labelled fluorodeoxyglucose for regional cerebral metabolic rate for glucose (rCMRGI) and oxygen-l 5 for regional cerebral blood flow (rCBF) and regional cerebral metabolic rate for oxygen (rCMRO). Quantitative rCMRGI studies in the interictal phase of partial epilepsy reveal five different patterns of significantly abnormal metabolic changes.